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04

Notes

Working thoughts and partial conclusions

incomplete by design
representation learning

On modality-invariant geometry

When ECG and echo embeddings share geometric structure, the model learns something closer to cardiac state than either modality alone. The missing modality problem becomes a projection problem.

protein design

Noncanonical amino acids as design space

Standard amino acids are just the beginning. ncAAs expand the chemical vocabulary available for protein engineering. Logic gates become possible at the molecular level.

data curation

Clinical data is never clean

35,000 scans became 1,000 usable cases. The curation process is the research. Understanding why data fails alignment reveals more about the clinical workflow than the data itself.

neural engineering

MRI-negative epilepsy

When imaging shows nothing, other signals must speak. EEG features, metabolic proxies, clinical semiology—triangulating the epileptogenic zone from its functional shadows.

systems

Infrastructure as constraint

HPC pipelines force you to think in terms of batches, queues, and resource allocation. The computational substrate shapes what questions you can afford to ask.

→ working thoughts

These are working thoughts—incomplete by design.